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Korean J Pancreas Biliary Tract. 2018;23(4):177-181

Publication date (electronic) : 2018 October 31

doi : https://doi.org/10.15279/kpba.2018.23.4.177

Suyun Oh, Chang-Nyol Paik

Division of Gastroenterology, Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, Korea

오수윤, 백창렬

가톨릭대학교 의과대학 가톨릭대학교 성빈센트병원 소화기내과

Corresponding author : Chang-Nyol Paik Division of Gastroenterology, Department of Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon 16247, Korea Tel. +82-31-249-7138 Fax. +82-31-253-8898 E-mail; cmcu@catholic.ac.kr

Received 2018 June 20; Revised 2018 August 17; Accepted 2018 August 18.

Abstract

Trans Abstract

INTRODUCTION

Diaphragmatic hernias may occur through the esophageal orifice or other congenital openings. The herniated contents of migration may contain the stomach with various other abdominal organs such as colon, omentum, small intestine, or spleen. Recently, a few literatures reported the association between diaphragmatic hernia and acute pancreatitis [1-4]. Furthermore, few [1] were reported in the case of pancreatitis due to hernia without evidence of incarceration. In this article, we present a case of acute pancreatitis due to diaphragmatic hernia with no evidence of herniation of pancreas.

CASE

A 78-year-old man presented with one-day history of severe epigastric pain and dyspnea. There was no relevant history of medicine, alcohol or trauma. Scores of years ago, the patient had a history of diaphragmatic hernia at routine check up in primary clinic, but he remained asymptomatic. Abdominal ultrasound 3 months prior in the primary clinic revealed no evidence of cholelithiasis. On physical examination, he had epigastric tenderness and bowel sounds in the left side of the chest. Chest X-ray revealed a large, dome-shaped loops of bowel with air-fluid level in the left hemithorax suggesting left diaphragmatic hernia (Fig. 1). Chest computed tomography (CT) showed extensive left diaphragmatic hernia, resulting in nearly complete collapse or consolidation in the left lung and mediastinal shifting to the right side (Fig. 2). Initial abdomen CT revealed mild pancreatitis which showed suspicious focal pancreatic parenchymal swelling at the pancreatic head area, but no remarkable pancreatic duct dilatation or pancreatic necrosis (Fig. 3). Abdomen CT showed no remarkable common bile duct stone. Serology test at time of initial admission revealed elevated serum amylase of 1,696 U/L (normal 45-108 U/L) and lipase of 2,425.4 U/L (normal 13-60 U/L). A complete blood cell count demonstrated a white blood cell count of 20,250/mm³ (normal 4,000-10,000/mm³), hemoglobin of 19.3 g/dL (normal 13-18 g/dL), and platelet count of 297,000/mm³ (normal 150,000-450,000/mm³). C-reactive protein was 0.71 mg/dL (normal 0-0.3 mg/dL). Blood glucose level was 230 mg/dL (normal 70-110 mg/dL). Other laboratory test workup showed that aspartate aminotransferase 45 IU/L (normal 5-38 IU/L), alanine aminotransferase 126 IU/L (normal 4-43 IU/L), alkaline phosphatase 313 IU/L (normal 102-333 IU/L), gamma glutamyl transpeptidase 290 U/L (normal 11-75 U/L), total bilirubin 2.70 mg/dL (normal 0.2-1.2 mg/dL) and triglyceride 63 mg/dL (normal 30-150 mg/dL). Immunologic data including serum immunoglobulin G, A, M, E levels were normal, and antinuclear antibody levels were negative, and anti-neutrophil cytoplasmic antibody, anti-mitochondria antibody, antismooth muscle antibody levels were negative. Serum IgG4 was not elevated at 0.27 g/L (normal 0.06-1.21 g/L) with total IgG 959 mg/dL (normal 700-1,600 mg/dL). Viral marker revealed negative HBs Hepatitis B surface antigen (HBsAg) positive Hepatitis B surface antigen (HBsAg) Hepatitis B surface antibody (HBsAb) and negative Hepatitis C antibody (HCV Ab) Ab. Arterial blood gas analysis showed bicarbonate retention up to 68.3 mmHg and the patient showed decreased mentality and he was initiated invasive ventilation in intensive care unit. The patient was treated with nasogastric tube drainage with intravenous fluid and empirical antibiotics, and the status of general condition was gradually recovered. On 3rd hospital day, follow-up chest posteroanterior view demonstrated that interval regression of left lung collapse and the volume of hernia was reduced (Fig. 4), and successful extubation was performed. On 10th hospital day, physical examination revealed no signs of any peritoneal irritation and abdominal pain, then a liquid or soft diet was started. The follow-up serology test demonstrated near normal level of serum amylase 119 U/L, and lipase 106 U/L. On 25th hospital day, follow-up chest xray showed interval re-expansion of left lung (Fig. 5), and abdomen CT demonstrated the sequela of acute pancreatitis, such as peripancreatic pseudocyst with the size 12 cm (Fig. 6). We recommended that the repair of the diaphragmatic hernia would be required. However, the patient refused to undergo surgery. The patient was discharged with no symptoms and a plan to follow-up for pancreatitis with diaphragmatic hernia. Thirty four months later, the patient remained asymptomatic and follow up CT was not performed because of patient’s refusal.

Fig. 1.

Chest X-ray showed a large, dome-shaped bowel gases in the left thorax indicating a left diaphragmatic hernia.

Fig. 2.

A chest computed tomography demonstrated left diaphragmatic hernia with content of stomach and small bowel with mediastinal shifting to the right side.

Fig. 3.

Abdomen computed tomography revealed focal pancreatic parenchymal swelling at the pancreatic head area suspicious of acute pancreatitis.

Fig. 4.

Follow-up chest X-ray on 3rd hospital day demonstrated that interval regression of left lung collapse and the volume of hernia in the left thorax was reduced.

Fig. 5.

Follow-up chest X-ray showed an increase of the volume of left lung and a decrease of bowel gases in the left thorax.

Fig. 6.

Follow-up abdomen computed tomography demonstrated newly developed cystic formation at the pancreatic head area, which indicates the sequela of acute pancreatitis, peripancreatic pseudocyst.

DISCUSSION

Acute pancreatitis associated with diaphragmatic hernia is an extremely rare condition in literature. The suggested mechanism is that herniation of pancreas itself may produce the traumas in vascular segmental branches or biliopancreatic conducts as well as sign of obstruction of the pancreatic duct [2,3]. The acute pancreatitis due to herniation could result in strangulation or incarceration of gland with or without pancreatic volvulus [2-4]. Another possibility is pancreatic ischemia due to traction after aggravation of hernia or acute distension of the stomach [1] which might be the cause of our case. The fact that the pancreas itself was not evident among the hernia content, and the main lesion of pancreatitis is the head of pancreas which is far from the site of herniation, may support the favor of the latter opinion that the cause of pancreatitis is pancreatic ischemia due to traction. The weak point of our case is that we couldn’t perform the magnetic resonance cholangiopancreatography or endoscopic ultrasonography because of poor patient’s condition. However, abdomen ultrasonography prior to admission revealed no evidence of gallstone, and medical treatment with expansion of lung alone had improved the pancreatitis. Accordingly, the cause of pancreatitis might be related with hernia itself. Although, fortunately, the conservative approach to reduce the hernia and to treat pancreatitis has an effect in our case, we believe that a fundamental therapeutic approach is repair of diaphragmatic hernia especially in case of acute pancreatitis associated with diaphragmatic hernia.

Given the limited number of cases reported so far [1-9], the most appropriate treatment of acute pancreatitis secondary to pancreatic herniation has not yet been established. Historically, patients were immediately treated with hiatal hernia repair [2]. Whereas, some recent reports [3,6,8] indicate that patients who have failed surgery due to high surgical risk or patient rejection have been successfully treated with supportive care (e.g., intravenous fluid supplementation, analgesia, early enteral feeding). However, in severe cases related to incarceration, perforation, or unresponsiveness to medical therapy, surgical management should be performed. Although they did not find pancreatitis cases which are similar to ours, Kohn et al. [9] reported in their literature that all symptomatic paraesophageal hernia should be repaired, particularly those with acute obstructive symptoms or those that have undergone volvulus.

The table 1 shows other cases of acute pancreatitis with diaphragmatic hernia and their treatment and prognosis. The recurrence rate of symptomatic paraesophageal hernia without surgical treatment is low, so the role of elective surgical reduction is uncertain. In addition, most affected patients are older and have significant comorbidities, making them poor operative candidates. Therefore, the decisions about surgical treatment should be made to individual patients. Elective repair may be considered in younger patients with low perioperative risk to prevent future complications.

Table 1.

Cases of acute pancreatitis with diaphragmatic hernia

When we encounter the patients with a history of hiatal hernia, diagnosed as pancreatitis without the evidence of the common causes of pancreatitis such as alcohol, stone, trauma, immunologic reaction, the diaphragmatic hernia should be considered for the underlying case of unknown pancreatitis. In addition, without evidence of herniation of pancreas, acute pancreatitis due to diaphragmatic hernia could occur.

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